Coronavirus

[GeddyWrox]

You know what catches the virus super early?

The [expletive] mRNA vaccine.

[cardinalkarp]

You know what catches the virus super early?

The [expletive] mRNA vaccine.

I’ve detailed all of the reasons too many times why I (and MANY others) am not comfortable w/ the vaccine.

The fact that we are at a point where people are essentially celebrating when an unvaccinated person gets COVID is disgusting.

And if this vaccine is the best we’ve got….guess what, we’re ALL [expletive].

[AdmiralKird]

As far as I can tell, the deal with ivermectin is that it does have anti-viral properties and in petri dish cultures in a lab it's shown promise. The problem is that you have to give a human a huge dose of it for it to be effective as an anti-viral, so much that you can't really take it because you're pooping your intestines out.

That’s what I’ve read

Some drugs have famously become known for treating things they were never designed for, but this isn't like the first lab tests on a heart drug named Viagra - Invermectin is already well-studied. Scientists have a pretty decent idea of how it functions, and those that have said it's unlikely to help against covid. It's akin to thinking a snowblower would do a good job to cut your lawn, like, yeah you can try it, but no matter what model you choose its probably not going to cut the grass.

[GeddyWrox]

We may indeed all be [expletive]. I don't disagree there. But no [expletive] way am I buying a drug formulated for farm animals and ingesting it. JFC.

The vaccine isn't a panacea cure but it's good enough to keep almost all of us out of ICU or from dying until this thing becomes endemic and we have actual approved therapeutics available OTC.

[Joe Shlabotnik]

You know what catches the virus super early?

The [expletive] mRNA vaccine.

I’ve detailed all of the reasons too many times why I (and MANY others) am not comfortable w/ the vaccine.

The fact that we are at a point where people are essentially celebrating when an unvaccinated person gets COVID is disgusting.

You don't see how disgusting it is that there are folks who won't take the proven safe and effective vaccine and so put everyone in continual danger?

So disappointing.

[AWvsCBsteeeerike3]

Preliminary results out of Israel from 3rd shot booster recipients since July 31st indicates a return to ~85-95% efficacy against infection. It's on John Campbell's yt channel if you're interested.

Watched a little bit of it earlier and heard the numbers.

They compiled ~4 million days of double vaxxed prior to the 3rd booster shot and compared it to ~3.4 million days post 3rd booster shot (defined as 12 days after the 3rd shot). The numbers were something like ~3500 infections in the first group vs ~300 infections.

Which is obviously good news. But, globally is it realistic to expect two/three shots annually?

[AdmiralKird]

Preliminary results out of Israel from 3rd shot booster recipients since July 31st indicates a return to ~85-95% efficacy against infection. It's on John Campbell's yt channel if you're interested.

Watched a little bit of it earlier and heard the numbers.

They compiled ~4 million days of double vaxxed prior to the 3rd booster shot and compared it to ~3.4 million days post 3rd booster shot (defined as 12 days after the 3rd shot). The numbers were something like ~3500 infections in the first group vs ~300 infections.

Which is obviously good news. But, globally is it realistic to expect two/three shots annually?

The hope is a third shot 5-8 months removed from the initial two will increase efficacy against infection for for a longer duration than the current rolling drop off of ~8% per month. Hopefully analysis from the next month will continue to show resilience against infection, and that should tell us how often a booster for pfizer/moderna might be needed for protection against infection/spreading.

[AWvsCBsteeeerike3]

Preliminary results out of Israel from 3rd shot booster recipients since July 31st indicates a return to ~85-95% efficacy against infection. It's on John Campbell's yt channel if you're interested.

Watched a little bit of it earlier and heard the numbers.

They compiled ~4 million days of double vaxxed prior to the 3rd booster shot and compared it to ~3.4 million days post 3rd booster shot (defined as 12 days after the 3rd shot). The numbers were something like ~3500 infections in the first group vs ~300 infections.

Which is obviously good news. But, globally is it realistic to expect two/three shots annually?

The hope is a third shot 5-8 months removed from the initial two will increase efficacy against infection for for a longer duration than the current rolling drop off of ~8% per month. Hopefully analysis from the next month will continue to show resilience against infection, and that should tell us how often a booster for pfizer/moderna might be needed for protection against infection/spreading.

Which would be great, but is there any reason to expect that?

I saw a study (4 people) that showed there were IgG antibodies (in the blood) as a result of the vax. And, to a lesser extent there were IgA produced (in the mucous). Neither of which are long lasting. But, overall, the adaptive arm is trained to the structure of the S2 protein after the first dose of the vax even if not producing many antibodies. Hence the reason, many - myself included, felt the vax would offer long lasting protection and generally has shown to still to this day at least against the severe forms of disease.

To me, all this means is the 3rd dose will result in increased antibodies with little change to the rest of the immune system. And, sure there may be a short period of time where IgA is present that helps prevent infection in general. A measure that is going to be amplified by the Israeli study only looking at, what, a week after the 3rd dose?

All that to say, is there a mechanism by which they expect an increased resiliency against infection other than short term antibody production?

I guess looking at the graph from the aforementioned study, maybe there's reason to believe IgA production will incrase and last longer? IDK. Tough to take much info from 4 patients and extrapolate it to what will happen. #1-3 in the graph are moderna recipients and #4 is pfizer recipient. I consider the vaccines similar enough to not really differentiate though even though I think moderna has a little bit higher dose.



https://journals.plos.org/plosone/artic ... ne.0249499

ETA: Looking at the graph more closely, it appears two of the patients studied only received iga measurements at day 30?, 40, and 80 with the spike happening at 40 then a decrease shown down to day 80. The other two that had measrements much more frequently between days 30 and 80 show a more precipitous decline in IgA. And also a lower peakk

[cardinalkarp]

We may indeed all be [expletive]. I don't disagree there. But no [expletive] way am I buying a drug formulated for farm animals and ingesting it. JFC.

The vaccine isn't a panacea cure but it's good enough to keep almost all of us out of ICU or from dying until this thing becomes endemic and we have actual approved therapeutics available OTC.

Stop saying it’s a drug formulated for farm animals….it’s just the narrative bs and has been shown to you numerous times in this thread alone that ivermectin is intended for human use.

[cardinalkarp]

You know what catches the virus super early?

The [expletive] mRNA vaccine.

I’ve detailed all of the reasons too many times why I (and MANY others) am not comfortable w/ the vaccine.

The fact that we are at a point where people are essentially celebrating when an unvaccinated person gets COVID is disgusting.

You don't see how disgusting it is that there are folks who won't take the proven safe and effective vaccine and so put everyone in continual danger?

So disappointing.

Safe and effective is in the eyes of the beholder. There are 10’s of thousands of documented cases where the vaccine has injured people, and effective at keeping people from dying and potential hospitalization…sure to an extent…but I’ll also contest that’s not a very effective vaccine.