Coronavirus

[GeddyWrox]

Apropos of all the posts AW has made w/r/t the passive arm of the immune response.

https://news.yahoo.com/pfizers-scientis ... 09783.html

[AWvsCBsteeeerike3]

Thanks for posting @GeddyWrox

The adaptive arm is really confusing me right now. On the one hand, most reports (like pfizers announcement there, and some other studies I've seen a while ago) indicated there was a strong adaptive arm (t cells in particular) response; however, that protection should be long lasting. It's not sterilizing immunity, and that's not its role in the immune system, but it should be (mostly) capable of preventing the virus from replicating to the point it can cause harm to the host even after antibodies made in response to the vaccine fade. But, given the latest recommendations for booster shots after 8 months, as well as possible real world data indicating the efficacy of the vaccine fades with time, those two ideas (robust t cell/adaptive arm response and loss of efficacy) directly conflict each other. Perhaps the t cell immunity also fades but that's....I Don't Know. I don't understand enough.

The only thing that could possibly make sense is any real world data that the regulatory agencies are relying on are limited to weakened immune systems in general (eldrly, immunocompromised, etc) but I have no data supporting that theory.

[Arthur Dent]

But, given the latest recommendations for booster shots after 8 months, as well as possible real world data indicating the efficacy of the vaccine fades with time, those two ideas (robust t cell/adaptive arm response and loss of efficacy) directly conflict each other. Perhaps the t cell immunity also fades but that's....I Don't Know. I don't understand enough.

From what I can tell, the data on fading immune response justifying universal boosters is not very strong and is difficult to disentangle from the confounding fact that the population with the longest “fade” time is also the most vulnerable people who got high vaccine priority. There are exceptions like health care workers, but that non-random sample is also challenging for other reasons.

[ghostrunner]

Another article on Ivermectin and the group promoting it:

https://www.huffpost.com/entry/horse-pa ... mg00000067

[cardinalkarp]

Another article on Ivermectin and the group promoting it:

https://www.huffpost.com/entry/horse-pa ... mg00000067

I read the article, but fact that they go w/ the “horse paste” narrative is all I need to know about their openness to the idea.

Has anyone watched the Joe Rogan podcast w/ him Cory and Weinstein? The fact that they call anyone who questions this vaccine anti-vaxx is horse [expletive]. Neither of those guys are “anti-vaxx”. Would I take ivermectin that is designed for livestock, hell no….but it’s not only a drug that’s been used effectively in humans for decades with very minimal side effects, it’s proven to be an anti-viral/anti-inflammatory….as well as an anti-parasitic. Whether you want to believe it’s helpful or not, that’s up to you and if you want to read the studies you mind be surprised at what you find. But if it can be at the minimum even a little effective at reducing symptoms keeping people out of the hospital why not give it a try?

I think it’s easy to identify why it’s not being used or no large scale studies will be done on it….like we’ve discussed before there is ZERO money to be made.

Once you realize this isn’t about saving lives and it’s all about making money these things make more sense.

[ghostrunner]

Prescribing Ivermectin on a massive scale would make a lot of money for a lot of people.

Also, the article is attempting to explain why people are taking horse medicine.

[GeddyWrox]

This is a great read about vaccine efficacy against Delta, why it's affecting children more this time, and why we should be vaxxed AND masking still. It also gets into the two arms of the immune response.

https://www.tampabay.com/opinion/2021/0 ... vid-column

[Jocephus]

260k cases yesterday, which looks like a top 5 number of cases. also 2100+ deaths. it'll be interesting if this fall/winter is worse than last year.

[AWvsCBsteeeerike3]

This is a great read about vaccine efficacy against Delta, why it's affecting children more this time, and why we should be vaxxed AND masking still. It also gets into the two arms of the immune response.

https://www.tampabay.com/opinion/2021/0 ... vid-column

What a great article and well written by that guy.

Though, I guess, my question would be, if vaccinated people are still able to be infected and spread the virus, and the virus has one of the highest R naughts of any virus they've ever seen due to its efficient ability to infect, how does it ever go away? Nasal vaccines that produce IgA would be great, but I don't think any are even out of Phase I trials yet. Does natural infection produce more IgA given that the infection almost assuredly came in through the nasal passage/throat? How long does IgA last, does it provide sterilizing immunity?

Sure, get vaxxed to protect yourself. Sure, wear masks to protect others. But, for how long? And, more importantly, is there a way this virus ever goes away? I'm not getting the warm and fuzzies given all that he said.

Certainly now preventative measures are needed to reduce demand on the hospitals. Is it going to be the same every year?

[ghostrunner]

This is a great read about vaccine efficacy against Delta, why it's affecting children more this time, and why we should be vaxxed AND masking still. It also gets into the two arms of the immune response.

https://www.tampabay.com/opinion/2021/0 ... vid-column

What a great article and well written by that guy.

Though, I guess, my question would be, if vaccinated people are still able to be infected and spread the virus, and the virus has one of the highest R naughts of any virus they've ever seen due to its efficient ability to infect, how does it ever go away? Nasal vaccines that produce IgA would be great, but I don't think any are even out of Phase I trials yet. Does natural infection produce more IgA given that the infection almost assuredly came in through the nasal passage/throat? How long does IgA last, does it provide sterilizing immunity?

Sure, get vaxxed to protect yourself. Sure, wear masks to protect others. But, for how long? And, more importantly, is there a way this virus ever goes away? I'm not getting the warm and fuzzies given all that he said.

Certainly now preventative measures are needed to reduce demand on the hospitals. Is it going to be the same every year?

I wonder if there's still research going into finding more effective vaccines. Having said that, if the current vaccines reduce severity to something like a cold that doesn't seem too bad.